AMPLIFIER SYSTEMS
Sutter Instrument provides a complete line of electrophysiology recording hardware and software, ideal for for applications ranging from tissue slice patch clamp over dissociated cell recordings to cell line studies.

dPATCH®
Unmatched sampling rate of up to 5 MHz
Supports the quietest single-channel recordings
Digital architecture for the highest signal fidelity
Ultra-stable compensation circuitry

IPA®
State-of-the-art amplifier technology
Fully integrated D/A and A/D conversion
High-speed pipette capacitance compensation
Bundled SutterPatch® Data Acquisition and Analysis Software

DENDRITE™
Up to 8 analog input channels available
Capable of 400 kHz aggregate sampling rate
High-speed USB connection controls data acquisition
4 analog output channels, 8 digital output channels

SutterPatch® Software
A full-featured electrophysiology data acquisition, management and analysis application backed by lifetime technical support.Amplifier System Resources
For all Sutter product information, view our technical support resources.- Videos
- Product Manuals
- Engineering Support
- Sample Publications
Manuals & Quick Start Guides
dPatch®
IPA®
Dendrite™
Contact a Sutter Expert
Telly Galiatsatos
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dPatch®
- Dolzer J (2021): Patch Clamp Technology in the Twenty-First Century. In: Dallas M., Bell D. (eds): Patch Clamp Electrophysiology. Methods in Molecular Biology 2188:21-49. doi:10.1007/978-1-0716-0818-0_2
- Spratt PWE, Alexander RPD, Ben-Shalom R, Sahagun A, Kyoung H, Keeshen CM, Sanders SJ, Bender KJ (2021): Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells. Cell Reports 36(5):109483. doi:10.1016/j.celrep.2021.109483
- Xia P, Laskur MAR, Wang, C (2023) Wafer-Scale Fabrication of Uniform, Micrometer-Sized, Triangular Membranes on Sapphire for High-Speed Protein Sensing in a Nanopore. ACS Appl Mater Interfaces 15(2):2656–2664. doi:10.1021/acsami.2c18983
- Brown SP, Lawson RJ, Moreno JD, Ransdell RL (2024): A Reinterpretation of the Relationship between Persistent and Resurgent Sodium Currents. J Neurosci 44 (29):e2396232024. doi:10.1523/JNEUROSCI.2396-23.2024
IPA®
- Liddiard GT, Suryavanshi PS, Glykys J (2024): Enhancing GABAergic Tonic Inhibition Reduces Seizure-Like Activity in the Neonatal Mouse Hippocampus and Neocortex. J Neurosci 44(7):e1342232023. doi:10.1523/JNEUROSCI.1342-23.2023
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Aimino MA, Coker CR, Silberman Y (2018) Acute ethanol modulation of neurocircuit function in the nucleus of the tractus solitarius. Brain Res Bull 138:5-11. doi:10.1016/j.brainresbull.2017.07.019
- Anderson EM, Gomez D, Caccamise A, McPhail D, Hearing M. (2019) Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neurons. Neurobiol Stress 10:100152. doi:10.1016/j.ynstr.2019.100152
- Avelar AJ, Akers AT, Baumgard ZJ, Cooper SY, Casinelli GP, Henderson BJ (2019) Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function. J Neuropharm 158:107729. doi:10.1016/j.neuropharm.2019.107729
- Doncheck EM, Anderson EM, Konrath CD, Liddiard GT, DeBaker MC, Urbanik LA, Hearing MC, Mantsch JR (2021): Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats. J Neurosci 41(24):5303-5314. doi:10.1523/JNEUROSCI.3086-20.2021
- Driscoll JR, Wallace TL, Mansourian KA, Martin WJ, Margolis EB (2020): Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System. eNeuro 7(5):ENEURO.0376-19.2020. doi:10.1523/ENEURO.0376-19.2020
- Feng T, Alicea C, Pham V, Kirk A, Pieraut S (2021): Experience-Dependent Inhibitory Plasticity Is Mediated by CCK+ Basket Cells in the Developing Dentate Gyrus. J Neurosci 41(21):4607-4619. doi:10.1523/JNEUROSCI.1207-20.2021
- Hu H, Wang X, Li C, Li Y, Hao J, Zhou Y,Yang X, Chen P, Shen X, Zhang S (2021): Loss of Dysbindin Implicates Synaptic Vesicle Replenishment Dysregulation as a Potential Pathogenic Mechanism in Schizophrenia. Neurosci 452:138-152. doi:10.1016/
- Hurley MM, Anderson EM Chen C, Maunze B, Hess EM, Block ME, Patel N, Cooper Z, McCoy R, Dabra T, Conley W, Reilly MJ, Hearing M, Choi S (2019) Acute Blockade of PACAP-Dependent Activity in the Ventromedial Nucleus of the Hypothalamus Disrupts Leptin-Induced Behavioral and Molecular Changes in Rats. Neuroendocrinol 110:271-281. doi:10.1159/000501337
- Hutto RA, Bisbach CM, Abbas F, Brock DC, Cleghorn WM, Parker ED, Bauer BH, Ge W, Vinberg F, Hurley JB, Brockerhoff SE (2019) Increasing Ca2+ in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress. Cell Death Differ 27:1067-1085. doi:10.1038/s41418-019-0398-2
- Madayag AC, Gomez D, Anderson EM, Ingebretson AE, Thomas MJ, Hearing MC (2019). Cell-type and region-specific nucleus accumbens AMPAR plasticity associated with morphine reward, reinstatement, and spontaneous withdrawal. Brain Struct Funct 224:2311. doi:10.1007/s00429-019-01903-y
- McDevitt DS, Jonik B, Graziane NM (2019) Morphine differentially alters the synaptic and intrinsic properties of D1R- and D2R-expressing medium spiny neurons in the nucleus accumbens. Front Synaptic Neurosci 11:35. doi:10.3389/fnsyn.2019.00035
- McGovern DJ, Polter AM, Root DH (2021): Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons. J Neurosci 41(25):5471-5486. doi:10.1523/JNEUROSCI.1419-20.2021
- Nissenkorn A, Almog Y, Adler I, Safrin M, Brusel M, Marom M, Bercovich S, Yakubovich D, Tzadok M, Ben-Zeev B, Rubinstein M (2019) In vivo, in vitro and in silico correlations of four de novo SCN1A missense mutations. PLoS ONE 14(2):e0211901. doi:10.1371/journal.pone.0211901
- Oda K, Vierock J, Oishi S, Rodriguez-Rozada S, Taniguchi R, Yamashita K, Wiegert JS, Nishizawa T, Hegemann P, Nureki O (2018) Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun 9(1):3949. doi:10.1038/s41467-018-06421-9
- Oppermann J, Fischer P, Silapetere A, Liepe B, Rodriguez-Rozada S, Flores-Uribe J, Peter E, Keidel A, Vierock J, Kaufmann J, Broser M, Luck M, Bartl F, Hildebrandt P, Wiegert JS, Béjà O, Hegemann P, Wietek J (2019) MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins. Nat Commun 10(1):3315. doi:10.1038/s41467-019-11322-6
- Qneibi M, Jaradat N, Emwas N (2019) Effect of Geraniol and Citronellol Essential Oils on the Biophysical Gating Properties of AMPA Receptors. Appl Sci 9(21):4693. doi:10.3390/app9214693
- Qneibi M, Hamed O, Natsheh AR, Jaradat N, Emwas N, AbuHasan Q, Al-Kerm R (2019) Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives. PLoS One 14(8):e0221132. doi:10.1371/journal.pone.0221132
- Qneibi M, Jaradat N, Hawash M, Olac A, Emwas N (2020): Ortho versus Meta Chlorophenyl-2,3-Benzodiazepine Analogues: Synthesis, Molecular Modeling, and Biological Activity as AMPAR Antagonists. ACS Omega 5(7):3588. doi:10.1021/acsomega.9b04000
- Qneibi M, Jaradat NA, Hawash M, Zaid AN, Natsheh AR, Yousef R, AbuHasan Q (2019) The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors. Biomed Res Int 2019:1-11. doi:10.1155/2019/5640173
- Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y (2019) Ipsilateral-Dominant Control of Limb Movements in Rodent Posterior Parietal Cortex. J Neurosci 39(3):485. doi:10.1523/JNEUROSCI.1584-18.2018
- Vierock J, Rodriguez-Rozada S, Dieter A, Pieper F, Sims R, Tenedini F, Bergs ACF, Bendifallah I, Zhou F, Ahlbeck J, Augustin S, Sauter K, Papagiakoumou E, Soba P, Emiliani V, Engel AK, Hegemann P, Zeitzschel N, Gottschalk A, Wiegert JS (2021): BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons. Nature Comm 12:2547. doi:10.1038/s41467-021-24759-5
- Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG, Soba P, Hegemann P, Wiegert JS (2017) Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.
Sci Rep 7:14957. doi:10.1038/s41598-017-14330-y