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XenoWorks®

Micromanipulator

The XenoWorks Micromanipulator is designed around our MP-285 electrophysiology micromanipulator mechanism, with the addition of a dynamic, ergonomic, hanging joystick. The three-axis mechanism inherits its vibration-resistance from the demands of electrophysiology research. Its stability makes the XenoWorks manipulator an ideal platform for intracytoplasmic sperm injection (ICSI), particularly when used together with our BRE Digital Pneumatic Injector and the Prime Tech Piezo Impact Drive System. The XenoWorks Micromanipulator is ideal for animal and cellular research that requires microinjection, aspiration, and transfers into eggs, cells or tissue, including CRISPR, nuclear transfer, and biopsy.

Our redesigned XenoWorks joystick offers an unprecedented level of user comfort. The new controller circuitry is fully integrated within the joystick, requires no fan, and is completely silent. The inverted, height- and tension-adjustable joystick, with its functionally shaped base, allows the operator to place their hands and forearms on the bench surface for superior ergonomics. The function keys and declutch band can be located and activated by touch, eliminating the need to look away from the microscope. Other time-saving features include the user-defined Home position, two user-defined Work positions, and the Setup function, which centers the mechanism along all three axes.

The Diagonal mode feature delivers easy axial movements along the length of the pipette. Combining diagonal mode with the new Pulse motion improves penetration of specimens with a resilient membrane, cuticle or chorion.

For maximum control, both the X- and Y-axes provide lock functions, providing pure linear movements in either horizontal direction.  When engaged, the Z-floor positional memory prevents the pipette from touching the bottom of the dish, reducing the risk of damage to the pipette or the preparation.  The X-axis positional limit is useful for repetitive injections, such as a row of eggs.

The XenoWorks joystick provides an intuitive feel for the pipette, making it easy to control placement, movement, and speed.  Movements of the joystick are converted directly into proportional movements of the pipette.  Controls for speed, center of travel, and pre-programmed positions are at the user’s fingertips.  By using the joystick’s unique declutch band, users can isolate movements of the joystick from the pipette, permitting a simple and natural ratcheting action for large movements.

The declutch band also acts as a modifier key, providing which giving individual buttons additional functions. Combining this advanced joystick with the Sutter’s proven Sutter manipulator technology creates an ideal system for efficient microinjection.

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  • Joystick and controller integrated into a single unit eliminates the need for a separate component
  • Inverted joystick with adjustable height and tension for optimal ergonomics
  • Exceptionally smooth and responsive micropipette movement
  • Diagonal mode operation for axial pipette movements
  • One-click, axial ‘Pulse’ operation helps penetrate tough membranes
  • User-defined “Home” position and “Work” positions for fast micropipette exchange
  • User-defined limits for travel along Z-axis and X-axis
  • Locks for X- and Y-axes permit pure movements along Y- and X-axes
  • 25 mm of travel in all three axes
  • Touch declutch mechanism
  • 8 speeds from coarse to ultra-fine
  • USB computer interface for external programmable control

TECHNICAL SPECIFICATIONS

Travel
25mm on all three axes

Maximum Resolution
125nm / microstep

Maximum Speed
3.25mm / sec

Range

Speed
Setting
X & Y Axis
(per swing of joystick)
Z axis
(per rotation of knob)
C 15.9 mm 3.2 mm
1 4.1 mm 800 µm
2 1.1 mm 400 µm
3 500 µm 200 µm
4 250 µm 100 µm
5 125 µm 50 µm
6 100 µm 30 µm
7 50 µm 10 µm


Joystick Controller Features

  • Inverted joystick
  • Adjustable height and tension
  • Independent control of X, Y, and Z axes
  • Setup function
  • Touch declutch
  • Z-floor axis limit
  • X-axis limit
  • Y-axis lock
  • X-axis lock
  • Diagonal Mode
  • 8 Speed settings
  • 1 user-defined Home position
  • 1 user-defined Work position
  • 2 user-defined axis limits: Z-Floor & X-Limit
  • Pulse Mode, 3 μm diagonal advance

Dimensions
Mechanical
4.4 x 7.3 x 5.7 in | 11.2 x 18.5 x 14.5 cm

Joystick Controller
11.4 x 9.3 x 9.6 in | 28.9 x 23.5 x 24.4 cm

Electrical
120/240 Volts
50/60 Hertz power line

 

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1615202270417

 

PRODUCT INFORMATION
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Part Number > XenoWorks Micromanipulator
International prices vary by country. Please contact your local distributor or Sutter Instrument for a quotation. Prices subject to change without notice.

Part Number Description
XWML XenoWorks Micromanipulator (Left) includes: 3 axis motor drive (left-hand configuration), motor drive base plate, joystick controller, connecting cables, and manual
XWMR XenoWorks Micromanipulator (Right) includes: 3 axis motor drive (right-hand configuration), motor drive base plate, joystick controller, connecting cables, and manual
XW-JOY XenoWorks Joystick Controller, power supply, and manual; for use with existing XenoWorks or MPC-285/M mechanicals

XenoWorks Microscope Adapters

Part Number Description
BR-L20 Leica DMIRB/E/IRE2 Adapter
BR-L30 Leica DMIL Adapter
BR-L40-2 Leica DMI 4/5/6000/8 Adapter (double-sided)
BR-N10 Nikon TMD Adapter
BR-N25 Nikon TE200/300 Adapter
BR-N27 Nikon TE2000 Adapter
BR-N29 Nikon Ti Adapter
BR-N29-M Nikon Ti Adapter for scopes w/ motorized stage
BR-Y50 Olympus IX50/70 Adapter
BR-Y51 Olympus IX51/71/81 Adapter
BR-Y51-FL Olympus IX51/71/81 Adapter w/ ZDC autofocus (left)
BR-Y51-FR Olympus IX51/71/81 Adapter w/ ZDC autofocus (right)
BR-Y73 Olympus IX53/73/83 Adapter
BR-Y73-2 Olympus IX53/73/83 Adapter (double-sided)
BR-Z30 Zeiss Axiovert 100/135 Adapter
BR-Z40 Zeiss Axiovert 200 / Axio Observer Adapter
BR-Z50 Zeiss Axiovert A1 Adapter
BR-CUST Custom microscope adapter, e.g., for aftermarket microscope stage or accessories

XenoWorks Accessories

Part Number Description
BR-AW Rod holding clamp (for rod OD 2 - 4mm), 2 in (5.0cm) long
BR-AW-L Rod holding clamp (for rod OD 2 - 4mm), 3 in (7.5cm) long
MT-81-DOV81 MT-81 gantry stand with 8 inch (20cm) dovetail; Clearance 1.75 to 6.5 in (4.5 - 16.5cm) Mounting height 2.5 to 7.25in (6.4 - 18.4cm)
MAG-SB-MT Magnetic feet for small baseplate (set of 4)
X050055 Magnetic plate for gantry equipped with magnetic feet
BRM-ADPTR-PLT2 XenoWorks adapter mounting plate with dovetail fitting;
5.75 x 6 x 0.3 in (14.5 x 15.5 x 0.8 cm)
BR-HEA-CV3 Swing gate conversion for MP-285 / MP-225

1 Useful with stereo or dissection scopes
2 Included with XenoWorks Microscope Adapters
3 Factory installation required. No charge when ordered with manipulator

Applications

  • Assisted Animal Reproduction
  • Pronuclear microinjection
  • Embryonic stem cell transfer
  • Nuclear transfer (ES cell)
  •  (ICSI)
  • Piezo-assisted sperm-mediated transgenesis
  • Nuclear transfer (NT)
  • Adherent cell microinjection
  • Drosophila injection
  • C. Elegans injection
  • Zebrafish injection

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